Understand ovulation induction, the options to discuss with a qualified clinician and what to confirm before planning a visit to Shiraz.
Key points
- Discuss your individual suitability, alternatives and risks with the treating clinician.
- Ask for written preparation and recovery instructions, including your medicines and follow-up.
- Confirm the healthcare facility, full costs and arrangements before booking travel.
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Some women ovulate infrequently or do not ovulate at all. Irregular ovulation or anovulation (not ovulating at all) results in irregular periods. These can have a number of reasons but the major ones are stress, weight fluctuations and PCOS (Polycystic Ovarian Syndrome). Thyroid and pituitary gland disorders raised prolactin level, and ovarian failure are some of the other reasons for not having regular ovulation. Ovarian failure may happen as a result of cancer treatment or menopause.
Therefore, when a woman is not ovulating by herself and if she is in a childbearing age and she is not developing mature follicles every month or does so but not as regular as other women, it might be impossible or very tough for her to get pregnant. Aside from that, irregular periods have a big impact on a woman’s mood, sleep, hair, skin and generally on her daily life quality. This is where “ovulation induction” is recommended to the person suffering from this condition.
To determine the follicles development, a pelvic ultrasound is performed to reach the endometrium (lining of the womb). Blood tests may also be done to measure hormone levels to identify a woman’s most fertile time of the month (a time when a woman is most likely to ovulate every month).
In order to successfully treat ovulation problems, the root cause must be identified. To this end, several blood tests and an ultrasound of the womb must be done. With the blood tests, the levels of thyroid hormones, prolactin, FSH, testosterone and other androgens (male hormones) must be measured. The ovary must be also evaluated in order to see whether it is capable of responding to the treatment or not. High concentration of FSH (FSH>10) and low AMH concentration at the beginning of the period, is indicative of a probable ovarian failure. In such cases, the treatment will not be useful, so if anovulation and oligoovulation are secondary to another disease, the “ovulation induction” treatment will not work unless the root cause is taken care of.
Ovulation induction methods
There are several methods for ovulation induction, depending on how responsive are the ovaries to each method.
- Ovulation induction using one of the medication regimens, which we will discuss below
- Ovarian drilling
- Metformin (especially prescribed for women with PCOS)
Ovulation induction using medication
Ovulation induction is induced with one of the following drug regimens:
Clomiphene citrate or Clomid tablets
How effective is Clomiphene citrate?
The effectiveness of Clomid is dependent on a number of reasons, such the age, infertility issues and seminal parameters.
Clomiphene citrate usually has no immediate serious side effects, but blurred vision, hot flushes, and mood swings may happen.
Gonadotropins or Gonadotrophins
Gonadotrophins are known with these trade names:
- Gonal F
- Menopur
- Bravelle
- Follistim
Human Chorionic Gonadotropin (HCG)
HCG, also known as Novarel, Profasi or Ovidrel is used as an injective ovulation induction method when there are sufficient amounts of matured follicles. With ultrasound, it’s easy to keep track of how responsive is the patient to the drugs. It can then be possible to know when the follicles have grown to their appropriate size, when intercourse is advised and HCG injection might be needed to help with the timing of intercourse or IUI (the process of transferring the semen directly into the uterus). Each patient has different responses to the ovulation induction. The response might be either too strong or not sufficient. In such cases, the current cycle may need to be canceled and a new one will need to be started. If the response turns out to be satisfactory, the treatment can be continued for another 6 consecutive cycles, without break and interruption.
Letrozole
Gonadotropin-releasing hormone (GnRH) analogs
Other ovulation induction options especially for women with PCOS
Women with PCOS who do not ovulate or do not ovulate regularly may be treated with Clomid at first, which in most cases has a satisfactory response. But there are two other options to consider:
Ovarian drilling
Ovarian drilling is an ovulation induction method suitable for women with PCOS
Ovulation induction in Iran
In Iran, all ovulation induction methods are performed by qualified specialists. For people with PCOS Iranian doctors usually prescribe clomiphene citrate as the first option to help women to ovulate. For patients who are planning to conceive, other methods may need to be performed. In terms of advancement, Iran’s fertility treatment services are in sync with developed countries.
A practical point for your care
Before an operation, the pre-assessment team should review your health, previous tests and all medicines and supplements. Ask for written instructions on medicines, eating, drinking and aftercare that apply to your planned procedure.[1]
Planning treatment in Shiraz
Ask SanaMedTour about the appropriate specialty, appointment arrangements and practical support for your visit. The treating clinician confirms the diagnosis, treatment options, suitability and follow-up after assessment.
Request an itemised written quote identifying the clinician, facility, tests, treatment, medicines, reviews and any accommodation or transfers included.
Sources
[1] NHS: Preparing for surgery — supports the individual-care planning note above. ↑ Back to text
Editorial adaptation: 25 October 2026. General information for planning and discussion; your clinician’s individual instructions take priority.